C₂₂H₁₅F₄N₃O₂

Base Information

• Chemical Name: C₂₂H₁₅F₄N₃O₂
• CAS No.: 1276035-85-8
• Molecular Formula: C₂₂H₁₅F₄N₃O₂
• Molecular Weight: 429.374
• Mol file: 1276035-85-8.mol

Synonyms:C₂₂H₁₅F₄N₃O₂

Chemical Property of C₂₂H₁₅F₄N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₁₅F₄N₃O₂

There total 6 articles about C₂₂H₁₅F₄N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H18F4N2O3 (1276040-22-2) + trimethyl orthoformate (149-73-5) → C22H15F4N3O2 (1276035-85-8)

Guidance literature:

C₂₂H₁₈F₄N₂O₃; With water; sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 20h;

With ammonium bicarbonate; HATU; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 1h;

trimethyl orthoformate; With trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield:

2-fluoro-5-iodobenzoic acid (124700-41-0) → C22H15F4N3O2 (1276035-85-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide; acetonitrile / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 2 h / Reflux

3.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 20 °C

4.1: potassium carbonate / dimethyl sulfoxide / 70 °C

4.2: 2 h / 70 °C

4.3: 6 h / 2 °C

5.1: potassium carbonate / dimethyl sulfoxide / 85 °C

6.1: water; sodium hydroxide / dimethyl sulfoxide / 20 h / 20 °C

6.2: 1 h / 20 °C

6.3: 1 h / 20 °C

With sodium periodate; osmium(VIII) oxide; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

methyl 2-fluoro-5-iodo-benzoate (625471-27-4) → C22H15F4N3O2 (1276035-85-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 2 h / Reflux

2.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 70 °C

3.2: 2 h / 70 °C

3.3: 6 h / 2 °C

4.1: potassium carbonate / dimethyl sulfoxide / 85 °C

5.1: water; sodium hydroxide / dimethyl sulfoxide / 20 h / 20 °C

5.2: 1 h / 20 °C

5.3: 1 h / 20 °C

With sodium periodate; osmium(VIII) oxide; water; potassium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; tert-butyl alcohol;

upstream raw materials:

2-fluoro-5-iodobenzoic acid

methyl 2-fluoro-5-iodo-benzoate

methyl 2-fluoro-5-formylbenzoate

C₂₂H₁₈F₄N₂O₃