Methyl2-fluoro-5-iodobenzoate

Base Information

• Chemical Name: Methyl2-fluoro-5-iodobenzoate
• CAS No.: 625471-27-4
• Molecular Formula: C8H6FIO2
• Molecular Weight: 280.037
• Hs Code.: 2916399090
• Mol file: 625471-27-4.mol

Synonyms:Methyl 2-Fluoro-5-iodobenzoate;Methyl-2-fluor-5-iodbenzolcarboxylat;2-Fluoro-5-iodobenzoic acid methyl ester;

Chemical Property of Methyl2-fluoro-5-iodobenzoate

Chemical Property:

• Vapor Pressure: 0.00176mmHg at 25°C
• Refractive Index: 1.577
• Boiling Point: 293.1 °C at 760 mmHg
• Flash Point: 131.1 °C
• Density: 1.823 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Fluoro-5-iodobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl2-fluoro-5-iodobenzoate

There total 7 articles about Methyl2-fluoro-5-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-fluoro-5-iodobenzoic acid (124700-41-0) + methyl iodide (74-88-4) → methyl 2-fluoro-5-iodo-benzoate (625471-27-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 80.0%

methanol (67-56-1) + 2-fluoro-5-iodobenzoic acid (124700-41-0) → methyl 2-fluoro-5-iodo-benzoate (625471-27-4)

Guidance literature:

With thionyl chloride; at 0 ℃; for 20h; Reflux;

DOI:10.1021/acs.organomet.8b00325

Reference yield: 34.0%

2-fluoro-5-iodobenzoic acid (124700-41-0) + dimethyl sulfate (77-78-1) → methyl 2-fluoro-5-iodo-benzoate (625471-27-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 2h;

upstream raw materials:

methyl 5-amino-2-fluorobenzoate

2-fluoro-5-iodobenzoic acid

methyl iodide

dimethyl sulfate

Downstream raw materials:

methyl 2-fluoro-5-vinylbenzoate

(4-fluoro-3-(methoxycarbonyl)phenyl)boronic acid

5-(4-bromobenzoyl)-2-fluorobenzoic acid methyl ester

methyl 2-fluoro-5-(4-nitrobenzoyl)benzoate