N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide

Base Information

Chemical Name:N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide
CAS No.:1443011-77-5
Molecular Formula:C₂₅H₂₅N₃O₂S₂
Molecular Weight:463.624
Hs Code.:

Synonyms:N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide

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Chemical Property of N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide

Chemical Property:

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Technology Process of N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide

There total 3 articles about N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 98-03-3
thiophene-2-carbaldehyde

: 1443011-83-3
C₁₅H₁₇N₃O₂

: 1443011-77-5
N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide

Guidance literature:: With sodium cyanoborohydride; zinc(II) chloride; In methanol; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.04.036

Reference yield:

: 100-46-9
benzylamine

: 1443011-77-5
N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; diisopropyl-carbodiimide; triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C

2: tin(II) chloride dihdyrate / ethanol / 0.5 h / 80 °C

3: sodium cyanoborohydride; zinc(II) chloride / methanol / 1.5 h / 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; sodium cyanoborohydride; benzotriazol-1-ol; triethylamine; zinc(II) chloride; diisopropyl-carbodiimide; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.036

Reference yield:

: 10463-37-3
(4-hydroxy-3,5-dinitro-phenyl)-acetic acid

: 1443011-77-5
N-benzyl-2-{4-hydroxy-3,5-bis[(thiophen-2-ylmethyl)amino]phenyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; diisopropyl-carbodiimide; triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C

2: tin(II) chloride dihdyrate / ethanol / 0.5 h / 80 °C

3: sodium cyanoborohydride; zinc(II) chloride / methanol / 1.5 h / 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; sodium cyanoborohydride; benzotriazol-1-ol; triethylamine; zinc(II) chloride; diisopropyl-carbodiimide; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.036