[2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane

Base Information

• Chemical Name: [2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane
• CAS No.: 604800-40-0
• Molecular Formula: C₁₆H₂₃IOSi
• Molecular Weight: 386.348
• Mol file: 604800-40-0.mol

Synonyms:[2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane

Chemical Property of [2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane

There total 6 articles about [2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N,N-diethyl-N'-[2-trimethylsilylethynyl-5-((S)-2-methylbutoxy)phenyl]triazene → [2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane (604800-40-0)

Guidance literature:

With methyl iodide; at 110 ℃; for 12h;

DOI:10.1021/ol0352254

Reference yield:

(2S)-2-methyl-1-butanol (1565-80-6) → [2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane (604800-40-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 94 percent / PPh₃; DIAD / tetrahydrofuran / 0 - 20 °C

2.1: FeCl₃*6H₂O; N₂H₄*H₂O / carbon black / methanol / 2 h / 70 °C

3.1: HCl; NaNO₂ / acetonitrile; H₂O / 0.5 h / -5 - 0 °C

3.2: 65 percent / K₂CO₃ / acetonitrile; H₂O / 0.25 h / 20 °C

4.1: 90 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 12 h / 45 °C

5.1: 72 percent / CH₃I / 12 h / 110 °C

With hydrogenchloride; copper(l) iodide; di-isopropyl azodicarboxylate; iron(III) chloride; hydrazine hydrate; triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; bis-triphenylphosphine-palladium(II) chloride; pyrographite; In tetrahydrofuran; methanol; water; acetonitrile; 1.1: Mitsunobu reaction / 4.1: Sonogashira coupling reaction;

DOI:10.1021/ol0352254

Reference yield:

4-iodo-3-nitrophenol (113305-56-9) → [2-iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethylsilane (604800-40-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 94 percent / PPh₃; DIAD / tetrahydrofuran / 0 - 20 °C

2.1: FeCl₃*6H₂O; N₂H₄*H₂O / carbon black / methanol / 2 h / 70 °C

3.1: HCl; NaNO₂ / acetonitrile; H₂O / 0.5 h / -5 - 0 °C

3.2: 65 percent / K₂CO₃ / acetonitrile; H₂O / 0.25 h / 20 °C

4.1: 90 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 12 h / 45 °C

5.1: 72 percent / CH₃I / 12 h / 110 °C

With hydrogenchloride; copper(l) iodide; di-isopropyl azodicarboxylate; iron(III) chloride; hydrazine hydrate; triethylamine; triphenylphosphine; sodium nitrite; methyl iodide; bis-triphenylphosphine-palladium(II) chloride; pyrographite; In tetrahydrofuran; methanol; water; acetonitrile; 1.1: Mitsunobu reaction / 4.1: Sonogashira coupling reaction;

DOI:10.1021/ol0352254

upstream raw materials:

(2S)-2-methyl-1-butanol

4-iodo-3-nitrophenol

2-iodo-5-((S)-2-methyl-butoxy)-aniline

1-iodo-4-((S)-2-methyl-butoxy)-2-nitro-benzene

Downstream raw materials:

[2-[2-[2-Iodo-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-4-((S)-2-methyl-butoxy)-phenylethynyl]-trimethyl-silane

C₃₃H₄₇N₃O₂Si

C₄₆H₆₁N₃O₃Si

C₅₉H₇₅N₃O₄Si