(Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide

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Chemical Name:(Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide
CAS No.:1604835-41-7
Molecular Formula:C₂₇H₂₉N₃O₃
Molecular Weight:443.546
Hs Code.:

Synonyms:(Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide

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Chemical Property of (Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide

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Technology Process of (Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide

There total 4 articles about (Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1604835-55-3
N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide

: 1604835-41-7
(Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide

Guidance literature:: With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; In chloroform; at 50 ℃; for 24h; regioselective reaction;
DOI:10.1002/ejoc.201301507

Reference yield:

: 10333-67-2
methyl 2-(1H-pyrrol-1-yl)benzoate

: 1604835-41-7
(Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C

2: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

3: sodium sulfate / methanol / 48 h / 20 °C

4: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate / chloroform / 24 h / 50 °C

With lithium aluminium tetrahydride; (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; silica gel; sodium sulfate; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; chloroform; 3: |Ugi Condensation;
DOI:10.1002/ejoc.201301507

Reference yield:

: 31739-56-7
2-(1H-pyrrol-1-yl)benzaldehyde

: 1604835-41-7
(Z)-N-(tert-butyl)-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-benzo[b]pyrrolo[2,1-i][1,5]diazonine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 48 h / 20 °C

2: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate / chloroform / 24 h / 50 °C

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; sodium sulfate; In methanol; chloroform; 1: |Ugi Condensation;
DOI:10.1002/ejoc.201301507