N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide

Base Information

Chemical Name:N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide
CAS No.:1604835-55-3
Molecular Formula:C₂₇H₂₉N₃O₃
Molecular Weight:443.546
Hs Code.:

Synonyms:N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide

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Chemical Property of N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide

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Technology Process of N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide

There total 3 articles about N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 31739-56-7
2-(1H-pyrrol-1-yl)benzaldehyde

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 2393-23-9
4-methoxy-benzylamine

: 471-25-0
Propiolic acid

: 1604835-55-3
N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide

Guidance literature:: With sodium sulfate; In methanol; at 20 ℃; for 48h;
DOI:10.1002/ejoc.201301507

Reference yield:

: 10333-67-2
methyl 2-(1H-pyrrol-1-yl)benzoate

: 1604835-55-3
N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C

2: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

3: sodium sulfate / methanol / 48 h / 20 °C

With lithium aluminium tetrahydride; silica gel; sodium sulfate; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; 3: |Ugi Condensation;
DOI:10.1002/ejoc.201301507

Reference yield:

: 61034-86-4
2-(pyrrol-1-yl)-benzyl alcohol

: 1604835-55-3
N-{1-[2-(1H-pyrrol-1-yl)phenyl]-2-(tert-butylamino)-2-oxoethyl}-N-(4-methoxybenzyl)propiolamide

Guidance literature:: Multi-step reaction with 2 steps

1: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

2: sodium sulfate / methanol / 48 h / 20 °C

With silica gel; sodium sulfate; pyridinium chlorochromate; In methanol; dichloromethane; 2: |Ugi Condensation;
DOI:10.1002/ejoc.201301507