4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:1094060-69-1
Molecular Formula:C₂₅H₂₆N₄O₂
Molecular Weight:414.507
Hs Code.:

Synonyms:4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Chemical Property:

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Technology Process of 4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 13 articles about 4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1094060-70-4
N-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2-formylhydrazinecarboxamide

: 1094060-69-1
4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With sodium hydroxide; In water; butan-1-ol; Reflux;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1094060-69-1
4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 55 °C

8.2: 20 °C

9.1: triethylamine; isobutyl chloroformate / acetone / 1 h / 20 °C

9.2: 0 °C

9.3: Reflux

10.1: hydrogenchloride; water / 1,4-dioxane / 0 - 20 °C

11.1: pyridine / dichloromethane / 0.5 h / 0 °C

11.2: 0 °C

12.1: sodium hydroxide / water; butan-1-ol / Reflux

With pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; iodine; sodium carbonate; caesium carbonate; magnesium; triethylamine; potassium iodide; lithium chloride; sodium hydroxide; isobutyl chloroformate; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; butan-1-ol;

Reference yield:

: 131379-16-3
4-(ethoxycarbonyl)phenylzinc iodide

: 1094060-69-1
4-(4-{2,2-dimethyl-1-[4-(pyridin-2-ylmethoxy)phenyl]propyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 50 °C

2.2: 20 °C

2.3: 0.5 h

3.1: iodine; magnesium; lithium chloride / tetrahydrofuran / 50 °C

3.2: 0 - 20 °C

4.1: sodium carbonate / N,N-dimethyl-formamide

5.1: hydrogen / palladium hydroxide, 20 wt% on carbon / ethanol / 72 h / 760.05 Torr

6.1: Chiralpak_.(R). AD / methanol / Resolution of racemate

7.1: caesium carbonate; potassium iodide / N,N-dimethyl-formamide

8.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 1 h / 55 °C

8.2: 20 °C

9.1: triethylamine; isobutyl chloroformate / acetone / 1 h / 20 °C

9.2: 0 °C

9.3: Reflux

10.1: hydrogenchloride; water / 1,4-dioxane / 0 - 20 °C

11.1: pyridine / dichloromethane / 0.5 h / 0 °C

11.2: 0 °C

12.1: sodium hydroxide / water; butan-1-ol / Reflux

With pyridine; hydrogenchloride; lithium hydroxide monohydrate; water; hydrogen; iodine; sodium carbonate; caesium carbonate; magnesium; triethylamine; potassium iodide; lithium chloride; sodium hydroxide; isobutyl chloroformate; bis-triphenylphosphine-palladium(II) chloride; palladium hydroxide, 20 wt% on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; butan-1-ol;