C₁₉H₂₂BFN₂O₆

Base Information

• Chemical Name: C₁₉H₂₂BFN₂O₆
• CAS No.: 1401342-92-4
• Molecular Formula: C₁₉H₂₂BFN₂O₆
• Molecular Weight: 404.203
• Mol file: 1401342-92-4.mol

Synonyms:C₁₉H₂₂BFN₂O₆

Chemical Property of C₁₉H₂₂BFN₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₂BFN₂O₆

There total 4 articles about C₁₉H₂₂BFN₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(R)-3-(4-bromo-3-fluorophenyl)-5-((isoxazol-3-yloxy)methyl)oxazolidin-2-one (1401342-89-9) + bis(pinacol)diborane (73183-34-3) → C19H22BFN2O6 (1401342-92-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In N,N-dimethyl-formamide; at 90 ℃; for 15h; Inert atmosphere;

Reference yield:

(4-bromo-3-fluorophenyl)carbamic acid benzyl ester (510729-01-8) → C19H22BFN2O6 (1401342-92-4)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium tert-butoxide / N,N-dimethyl-formamide; methanol; tetrahydrofuran / 3 h / 0 - 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-isopropyl azodicarboxylate; potassium acetate; triphenylphosphine; lithium tert-butoxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

3-fluoro-4-bromophenylamine (656-65-5) → C19H22BFN2O6 (1401342-92-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / dichloromethane / 1 h / 20 °C

2: lithium tert-butoxide / N,N-dimethyl-formamide; methanol; tetrahydrofuran / 3 h / 0 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 90 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-isopropyl azodicarboxylate; potassium acetate; triphenylphosphine; sodium hydroxide; lithium tert-butoxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

3-fluoro-4-bromophenylamine

(4-bromo-3-fluorophenyl)carbamic acid benzyl ester

(R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxylmethyl)oxazolidin-2-one

(R)-3-(4-bromo-3-fluorophenyl)-5-((isoxazol-3-yloxy)methyl)oxazolidin-2-one