2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide

Base Information

Chemical Name:2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide
CAS No.:1374149-79-7
Molecular Formula:C₂₃H₂₂F₂N₆O
Molecular Weight:436.464
Hs Code.:

Synonyms:2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide

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Chemical Property of 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide

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Technology Process of 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide

There total 7 articles about 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374150-51-2
C₂₂H₁₉F₂N₅O₂

: 74-89-5
methylamine

: 1374149-79-7
2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide

Guidance literature:: C₂₂H₁₉F₂N₅O₂; With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1374149-79-7
2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16 h / 60 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 100 °C

3.1: zinc; ammonium formate / ethanol / 2 h / 50 °C

4.1: Oxone / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 1 h / 20 °C

With Oxone; ammonium formate; potassium carbonate; triethylamine; HATU; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1374149-79-7
2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-4,5-difluoro-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 2 h / 100 °C

2.1: zinc; ammonium formate / ethanol / 2 h / 50 °C

3.1: Oxone / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 1 h / 20 °C

With Oxone; ammonium formate; potassium carbonate; triethylamine; HATU; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;