Technology Process of C25H28F2N4O*ClH
There total 8 articles about C25H28F2N4O*ClH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C15H22FN3; C10H6FNO2;
With
sodium tris(acetoxy)borohydride;
In
dichloromethane;
at 20 ℃;
for 14h;
Molecular sieve;
With
hydrogenchloride;
In
diethyl ether;
Molecular sieve;
DOI:10.5012/bkcs.2012.33.12.4227
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-chloro-succinimide; pyridine / tetrahydrofuran / 0.67 h / 60 °C / Inert atmosphere
1.2: 2 h / 50 °C / Inert atmosphere
2.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Molecular sieve
3.1: sodium tris(acetoxy)borohydride / dichloromethane / 14 h / 20 °C / Molecular sieve
3.2: Molecular sieve
With
pyridine; N-chloro-succinimide; sodium tris(acetoxy)borohydride; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
DOI:10.5012/bkcs.2012.33.12.4227
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: dichloromethane / 1 h / 20 °C
2.1: pyridinium chlorochromate; silica gel / dichloromethane / 3 h / 20 °C
3.1: sodium tris(acetoxy)borohydride / dichloromethane / 6 h / 20 °C / Inert atmosphere; Molecular sieve
4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
5.1: sodium tris(acetoxy)borohydride / dichloromethane / 14 h / 20 °C / Molecular sieve
5.2: Molecular sieve
With
silica gel; sodium tris(acetoxy)borohydride; pyridinium chlorochromate; trifluoroacetic acid;
In
dichloromethane;
DOI:10.5012/bkcs.2012.33.12.4227