N-cyclohexyl-4-phenylbutanamide

Base Information

• Chemical Name: N-cyclohexyl-4-phenylbutanamide
• CAS No.: 64353-78-2
• Molecular Formula: C16H23NO
• Molecular Weight: 245.365
• Mol file: 64353-78-2.mol

Synonyms:4-Phenyl-buttersaeure-cyclohexylamid;4-phenylbutyric acid hydrazide;4-phenyl-butyric acid cyclohexylamide;4-phenyl-Mutyric Acid Hydrazide;4-Phenyl-buttersaeure-hydrazid;

Chemical Property of N-cyclohexyl-4-phenylbutanamide

Chemical Property:

• Vapor Pressure: 8.51E-08mmHg at 25°C
• Boiling Point: 435.8°Cat760mmHg
• Flash Point: 264.9°C
• PSA: 29.10000
• Density: 1.01g/cm³
• LogP: 3.84910

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclohexyl-4-phenylbutanamide

There total 6 articles about N-cyclohexyl-4-phenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N,N-diethyl-4-phenylbutanamide (56229-85-7) + cyclohexylamine (108-91-8,157973-60-9) → 4-phenyl-butyric acid cyclohexylamide (64353-78-2)

Guidance literature:

With chloro-trimethyl-silane; 1,10-Phenanthroline; tungsten(VI) chloride; In 1-methyl-pyrrolidin-2-one; at 140 ℃; for 36h;

DOI:10.1021/acscatal.1c01840

Reference yield:

4-phenylbutyric acid anhydride (1940-02-9) + 1,3-Dicyclohexylurea (2387-23-7) → 4-phenyl-butyric acid cyclohexylamide (64353-78-2) + Cyclohexyl isocyanate (3173-53-3) + 4-Phenylbutyric acid (1821-12-1)

Guidance literature:

In sulfolane; at 160 ℃; for 0.25h; other carboxylic anhydride;

Reference yield:

N-cyclohexyl-4-hydroxy-4-phenylbutanamide (101255-43-0) → 4-phenyl-butyric acid cyclohexylamide (64353-78-2)

Guidance literature:

With methanol; palladium on activated charcoal; Hydrogenation;

DOI:10.1021/ja01550a037

upstream raw materials:

N-cyclohexyl-4-hydroxy-4-phenylbutanamide

cyclohexylamine

phenylbutyric acid chloride

4-phenylbutyric acid anhydride

Refernces

• 1、 Schotman, A. H. M.. "Mechanism of the reaction of carbodiimides with carboxylic acids". . p. 319 - 324. Retrieved 2007/10/02.