Technology Process of (S,E)-(2-benzylidenecyclopentyl)benzene
There total 4 articles about (S,E)-(2-benzylidenecyclopentyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenylmagnesium bromide;
With
copper(l) chloride;
at 0 ℃;
for 0.25h;
Schlenk technique;
Inert atmosphere;
(R,E)-1-acetoxy-2-benzylidene cyclopentane;
In
tetrahydrofuran;
enantioselective reaction;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/ol302358j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 0.08 h / 20 °C
1.2: 72 h
2.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C
3.1: C12H16ClO2Ru; candida antarcticalipase B; sodium carbonate / toluene; tetrahydrofuran / 0.17 h / 40 °C / Inert atmosphere; Schlenk technique
3.2: 48 h / Schlenk technique; Inert atmosphere
4.1: copper(l) chloride / 0.25 h / 0 °C / Schlenk technique; Inert atmosphere
4.2: Schlenk technique; Inert atmosphere
With
sodium tetrahydroborate; candida antarcticalipase B; C12H16ClO2Ru; sodium carbonate; copper(l) chloride; sodium hydroxide;
In
tetrahydrofuran; methanol; water; toluene;
1.2: |Aldol Condensation;
DOI:10.1021/ol302358j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 0.08 h / 20 °C
1.2: 72 h
2.1: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C
3.1: C12H16ClO2Ru; candida antarcticalipase B; sodium carbonate / toluene; tetrahydrofuran / 0.17 h / 40 °C / Inert atmosphere; Schlenk technique
3.2: 48 h / Schlenk technique; Inert atmosphere
4.1: copper(l) chloride / 0.25 h / 0 °C / Schlenk technique; Inert atmosphere
4.2: Schlenk technique; Inert atmosphere
With
sodium tetrahydroborate; candida antarcticalipase B; C12H16ClO2Ru; sodium carbonate; copper(l) chloride; sodium hydroxide;
In
tetrahydrofuran; methanol; water; toluene;
1.2: |Aldol Condensation;
DOI:10.1021/ol302358j
