3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone

Base Information

Chemical Name:3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone
CAS No.:216979-24-7
Molecular Formula:C₂₈H₃₃N₅O₆
Molecular Weight:535.6
Hs Code.:

Synonyms:3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone

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Chemical Property of 3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone

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Technology Process of 3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone

There total 8 articles about 3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 147269-63-4
(3-Benzyloxycarbonylamino-6-methyl-2-oxo-1,2-dihydro-1-pyridyl)acetic acid

: 187163-72-0
2-tert-butoxycarbonylamino-5-aminomethyl-6-methyl-pyridine

: 216979-24-7
3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 64h;
DOI:10.1021/jm980368v

Reference yield:

: 42753-71-9
5-bromo-6-methyl-pyridin-2-ylamine

: 216979-24-7
3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / dimethylformamide / 4 h / Heating

2: 84 percent / Et₃N, DMAP / CH₂Cl₂

3: 69 percent / H₂ / Pd/C / acetic acid / 60 h / 3102.89 Torr

4: 84 percent / EDC hydrochloride, HOBT, Et₃N / dimethylformamide / 64 h

With dmap; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm980368v

Reference yield:

: 183428-90-2
2-amino-5-cyano-6-methylpyridine

: 216979-24-7
3-benzyloxycarbonylamino-6-methyl-1-(2-tert-butoxycarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / Et₃N, DMAP / CH₂Cl₂

2: 69 percent / H₂ / Pd/C / acetic acid / 60 h / 3102.89 Torr

3: 84 percent / EDC hydrochloride, HOBT, Et₃N / dimethylformamide / 64 h

With dmap; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm980368v