183428-90-2

Basic information

• Product Name: 6-AMINO-2-METHYLNICOTINONITRILE
• Synonyms: 6-AMINO-2-METHYLNICOTINONITRILE;6-AMINO-3-CYANO-2-METHYLPYRIDINE;6-AMINO-2-METHYLPYRIDINE-3-CARBONITRILE, 97%;6-Amino-3-cyano-2-methylpyridine 97%;3-Pyridinecarbonitrile,6-amino-2-methyl-(9CI);2-Amino-5-cyano-6-methylpyridine;6-amino-2-methyl-3-Pyridinecarbonitrile
• CAS NO: 183428-90-2
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15
• Product Categories: PYRIDINE;Amines and Anilines;Heterocycles;Pyridine series;Pyridines;Heterocyclic Compounds
• Mol File: 183428-90-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 155-156
• Boiling Point: 295.072 °C at 760 mmHg
• Flash Point: 132.255 °C
• Appearance: /
• Density: 1.184 g/cm³
• Vapor Pressure: 0.00156mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3?+-.0.37(Predicted)
• CAS DataBase Reference: 6-AMINO-2-METHYLNICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2-METHYLNICOTINONITRILE(183428-90-2)
• EPA Substance Registry System: 6-AMINO-2-METHYLNICOTINONITRILE(183428-90-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 183428-90-2(Hazardous Substances Data)

Usage

Uses

6-Amino-3-cyano-2-methylpyridine is a useful nitrile building block for proteomics research and synthesis.

InChI:InChI=1/C7H7N3/c1-5-6(4-8)2-3-7(9)10-5/h2-3H,1H3,(H2,9,10)

Upstream product

• 42753-71-9 5-bromo-6-methyl-pyridin-2-ylamine 
• 557-21-1 zinc(II) cyanide 
• 557-21-1 dicyanozinc 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 872355-55-0 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid 
• 872355-54-9 6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester 
• 872355-52-7 methyl 6-amino-2-methylpyridine-3-carboxylate 
• 1638983-52-4 (6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanamine 
• 1394003-57-6 6-amino-5-bromo-2-methylnicotinonitrile 
• 1300006-86-3 (R)-N-[(S)-1-[(6-amino-2-methyl-pyridin-3-ylmethyl)-carbamoyl]-2-(4-fluoro-phenyl)-ethyl]-2-hydroxy-3-phenyl-propionamide trifluoroacetate 

Relevant articles and documents

Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonists

A series of 6-aminonicotinic acid analogues have been synthesized and pharmacologically characterized at native and selected recombinant GABA A receptors. 6-Aminonicotinic acid (3) as well as 2- and 4-alkylated analogues (9-11, 14-16) display low to mid-micromolar GABAAR binding affinities to native GABAA receptors (Ki 1.1-24 μM). The tetrahydropyridine analogue of 3 (22) shows low-nanomolar affinity (K i 0.044 μM) and equipotency as an agonist to GABA itself as well as the standard GABAA agonist isoguvacine. Cavities surrounding the core of the GABA binding pocket were predicted by molecular interaction field calculations and docking studies in a α1β 2γ2 GABAA receptor homology model, and were confirmed by affinities of substituted analogues of 3. The tight steric requirements observed for the remarkably few GABAAR agonists reported to date is challenged by our findings. New openings for agonist design are proposed which potentially could facilitate the exploration of different pharmacological profiles within the GABAAR area.

AZAINDOLE DERIVATIVES AS INHIBITORS OF P38 KINASE

The invention is directed to methods to inhibit p38 kinase, preferably p38-α using compounds which are azaindoles wherein the azaindoles are coupled through an azacyclic linker to another cyclic moiety.

PYRAZINONE THROMBIN INHIBITORS

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