N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide

Base Information

Chemical Name:N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide
CAS No.:1201662-23-8
Molecular Formula:C₄₄H₃₉Cl₂FN₂O₅S
Molecular Weight:797.774
Hs Code.:

Synonyms:N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide

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Chemical Property of N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide

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Technology Process of N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide

There total 6 articles about N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1201663-76-4
3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxy-N-(3-((isobutylamino)methyl)benzyl)benzenesulfonamide

: 2243-42-7
2-phenoxybenzoic acid

: 1201662-23-8
N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 12h;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1201662-23-8
N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / Inert atmosphere; Reflux

2.2: 1.33 - 1.5 h / 0 °C

2.3: 1 h / 20 °C

3.1: triethylamine / dichloromethane / 0.25 - 0.33 h / 0 °C

3.2: 2 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.1: methanol / 3.17 h / 20 °C / Reflux

5.2: 0.5 h / 0 °C

5.3: 1 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis catalyst; In methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1201662-23-8
N-(3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzyl)-N-isobutyl-2-phenoxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / Inert atmosphere; Reflux

2.2: 1.33 - 1.5 h / 0 °C

2.3: 1 h / 20 °C

3.1: triethylamine / dichloromethane / 0.25 - 0.33 h / 0 °C

3.2: 2 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

5.1: methanol / 3.17 h / 20 °C / Reflux

5.2: 0.5 h / 0 °C

5.3: 1 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis catalyst; In methanol; dichloromethane; toluene; acetonitrile;