tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

Base Information

Chemical Name:tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate
CAS No.:1201663-74-2
Molecular Formula:C₃₂H₃₁Cl₂FN₂O₅S
Molecular Weight:645.579
Hs Code.:

Synonyms:tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

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Chemical Property of tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

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Technology Process of tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

There total 4 articles about tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1201663-73-1
tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate

: 23378-88-3
3,5-dichloro-2-hydroxybenzenesulfonyl chloride

: 1201663-74-2
tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

Guidance literature:: tert-butyl 3-(((4'-fluorobiphenyl-4-yl)methyl amino)methyl)benzylcarbamate; With triethylamine; In dichloromethane; at 0 ℃; for 0.25 - 0.333333h;

3,5-dichloro-2-hydroxybenzenesulfonyl chloride; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1201663-74-2
tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / Inert atmosphere; Reflux

2.2: 1.33 - 1.5 h / 0 °C

2.3: 1 h / 20 °C

3.1: triethylamine / dichloromethane / 0.25 - 0.33 h / 0 °C

3.2: 2 h / 0 °C

With potassium carbonate; triethylamine; tetrakis catalyst; In methanol; dichloromethane; toluene;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1201663-74-2
tert-butyl 3-((3,5-dichloro-N-((4'-fluorobiphenyl-4-yl)methyl)-2-hydroxyphenylsulfonamido)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis catalyst / toluene / 12 h / Inert atmosphere; Reflux

2.1: methanol / 4 h / Inert atmosphere; Reflux

2.2: 1.33 - 1.5 h / 0 °C

2.3: 1 h / 20 °C

3.1: triethylamine / dichloromethane / 0.25 - 0.33 h / 0 °C

3.2: 2 h / 0 °C

With potassium carbonate; triethylamine; tetrakis catalyst; In methanol; dichloromethane; toluene;