Technology Process of 1-phenyl-5-({6,7,7-trifluoro-3-methyl-3-[(trimethylsilyl)oxy]-6-hepten-1-yl}sulfonyl)-1H-tetrazole
There total 8 articles about 1-phenyl-5-({6,7,7-trifluoro-3-methyl-3-[(trimethylsilyl)oxy]-6-hepten-1-yl}sulfonyl)-1H-tetrazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 5h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
1.2: 0.5 h / -78 °C
2.1: lithium borohydride / tert-butyl methyl ether / 4 h / 20 °C / Cooling with ice
2.2: Cooling with ice
3.1: sodium hydroxide; p-toluenesulfonyl chloride; tetrabutylammomium bromide / toluene / 0.5 h / Cooling with ice
3.2: 60 °C
4.1: sodium hypochlorite; potassium bromide / acetonitrile; water / 2 h / Cooling with ice
5.1: diethyl ether; tetrahydrofuran / 1 h / -78 °C / Cooling with ice
6.1: dihydrogen peroxide; ammonium heptamolybdate tetrahydrate / water; methanol / 20 °C / Cooling with ice
7.1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C / Cooling with ice
With
1H-imidazole; sodium hypochlorite; lithium borohydride; ammonium heptamolybdate tetrahydrate; tetrabutylammomium bromide; dihydrogen peroxide; p-toluenesulfonyl chloride; potassium bromide; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; diethyl ether; tert-butyl methyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium borohydride / tert-butyl methyl ether / 4 h / 20 °C / Cooling with ice
1.2: Cooling with ice
2.1: sodium hydroxide; p-toluenesulfonyl chloride; tetrabutylammomium bromide / toluene / 0.5 h / Cooling with ice
2.2: 60 °C
3.1: sodium hypochlorite; potassium bromide / acetonitrile; water / 2 h / Cooling with ice
4.1: diethyl ether; tetrahydrofuran / 1 h / -78 °C / Cooling with ice
5.1: dihydrogen peroxide; ammonium heptamolybdate tetrahydrate / water; methanol / 20 °C / Cooling with ice
6.1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C / Cooling with ice
With
1H-imidazole; sodium hypochlorite; lithium borohydride; ammonium heptamolybdate tetrahydrate; tetrabutylammomium bromide; dihydrogen peroxide; p-toluenesulfonyl chloride; potassium bromide; sodium hydroxide;
In
tetrahydrofuran; methanol; diethyl ether; tert-butyl methyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile;
