Technology Process of N-(2-bromo-5-chlorophenyl)propiolamide
There total 1 articles about N-(2-bromo-5-chlorophenyl)propiolamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1055/s-0033-1339690
- Guidance literature:
-
N-(2-bromo-5-chlorophenyl)propiolamide;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.5h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; mineral oil;
at 0 - 25 ℃;
for 6h;
Inert atmosphere;
DOI:10.1055/s-0033-1339690
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 6 h / 0 - 25 °C / Inert atmosphere
2.1: copper(l) iodide; sodium acetate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 25 - 60 °C / Inert atmosphere
3.1: 24 h / 90 °C / Inert atmosphere
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); sodium acetate; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
2.1: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0033-1339690
