2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

Base Information

Chemical Name:2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate
CAS No.:1301608-46-7
Molecular Formula:C₂₃H₁₉ClN₆O₄S
Molecular Weight:510.961
Hs Code.:

Synonyms:2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

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Chemical Property of 2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

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Technology Process of 2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

There total 9 articles about 2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301608-36-5
(4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorophenyl)methanol

: 1301608-46-7
2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus tribromide / diethyl ether / 7 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

4: sulphamoyl chloride; dimethyl amine / 0 - 20 °C / Inert atmosphere

With sulphamoyl chloride; tetrabutyl ammonium fluoride; phosphorus tribromide; potassium carbonate; dimethyl amine; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1080/00397911003797825

Reference yield:

: 1301608-37-6
4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzylbromide

: 1301608-46-7
2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: sulphamoyl chloride; dimethyl amine / 0 - 20 °C / Inert atmosphere

With sulphamoyl chloride; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl amine; In tetrahydrofuran; acetonitrile;
DOI:10.1080/00397911003797825

Reference yield:

: 1301608-35-4
4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzaldehyde

: 1301608-46-7
2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 5 h / 0 - 20 °C

2: phosphorus tribromide / diethyl ether / 7 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5: sulphamoyl chloride; dimethyl amine / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; sulphamoyl chloride; tetrabutyl ammonium fluoride; phosphorus tribromide; potassium carbonate; dimethyl amine; In tetrahydrofuran; methanol; diethyl ether; acetonitrile;
DOI:10.1080/00397911003797825