3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

Base Information

Chemical Name:3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate
CAS No.:1301608-44-5
Molecular Formula:C₁₆H₁₃ClN₆O₄S
Molecular Weight:420.836
Hs Code.:

Synonyms:3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

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Chemical Property of 3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

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Technology Process of 3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

There total 17 articles about 3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1301608-46-7
2-(benzyloxy)-3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)phenyl sulfamate

: 1301608-44-5
3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1080/00397911003797825

Reference yield:

: 1301608-37-6
4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzylbromide

: 1301608-44-5
3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: sulphamoyl chloride; dimethyl amine / 0 - 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C

With palladium 10% on activated carbon; sulphamoyl chloride; tetrabutyl ammonium fluoride; hydrogen; potassium carbonate; dimethyl amine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1080/00397911003797825

Reference yield:

: 1301608-35-4
4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzaldehyde

: 1301608-44-5
3-chloro-5-(((4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino)methyl)-2-hydroxyphenyl sulfamate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tetrahydroborate / methanol / 5 h / 0 - 20 °C

2: phosphorus tribromide / diethyl ether / 7 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5: sulphamoyl chloride; dimethyl amine / 0 - 20 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 3 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; sulphamoyl chloride; tetrabutyl ammonium fluoride; hydrogen; phosphorus tribromide; potassium carbonate; dimethyl amine; In tetrahydrofuran; methanol; diethyl ether; acetonitrile;
DOI:10.1080/00397911003797825