4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile

Base Information

Chemical Name:4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile
CAS No.:1301608-38-7
Molecular Formula:C₂₉H₃₂ClN₅O₂Si
Molecular Weight:546.144
Hs Code.:

Synonyms:4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile

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Chemical Property of 4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile

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Technology Process of 4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile

There total 7 articles about 4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1301608-37-6
4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzylbromide

: 148869-66-3
4-[N-(1,2,4-triazol-4-yl)amino]benzonitrile

: 1301608-38-7
4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃;
DOI:10.1080/00397911003797825

Reference yield:

: 1301608-35-4
4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzaldehyde

: 1301608-38-7
4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / methanol / 5 h / 0 - 20 °C

2: phosphorus tribromide / diethyl ether / 7 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 20 °C

With sodium tetrahydroborate; phosphorus tribromide; potassium carbonate; In methanol; diethyl ether; acetonitrile;
DOI:10.1080/00397911003797825

Reference yield:

: 34098-18-5
5-chloro-3,4-dihydroxybenzaldehyde

: 1301608-38-7
4-((4-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-chlorobenzyl)(4H-1,2,4-triazol-4-yl)amino)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium carbonate / N,N-dimethyl-formamide / 1 h / Heating

1.2: 1 h / 45 °C

2.1: dmap; triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 5 h / 0 - 20 °C

4.1: phosphorus tribromide / diethyl ether / 7 h / 0 - 20 °C

5.1: potassium carbonate / acetonitrile / 20 °C

With dmap; sodium tetrahydroborate; phosphorus tribromide; lithium carbonate; potassium carbonate; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/00397911003797825