4-TERT-BUTYLBUTYROPHENONE

Base Information

• Chemical Name: 4-TERT-BUTYLBUTYROPHENONE
• CAS No.: 59477-80-4
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.312
• Mol file: 59477-80-4.mol

Synonyms:1-(4-(tert-butyl)phenyl)butan-1-one

Chemical Property of 4-TERT-BUTYLBUTYROPHENONE

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-TERT-BUTYLBUTYROPHENONE

There total 8 articles about 4-TERT-BUTYLBUTYROPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butylbenzene (253185-03-4,253185-04-5) + butyryl chloride (141-75-3) → 1-(4-(tert-butyl)phenyl)butan-1-one (59477-80-4)

Guidance literature:

butyryl chloride; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 0 ℃; for 0.166667h;

tert-butylbenzene; In 1,2-dichloro-ethane; at 50 ℃; for 1h;

DOI:10.1039/c5ob00684h

Reference yield: 82.0%

formic acid (64-18-6) + 1-tert-butyl-4-iodobenzene (35779-04-5) + propyl bromide (106-94-5) → 1-(4-(tert-butyl)phenyl)butan-1-one (59477-80-4)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; acetic anhydride; magnesium; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; at 55 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201800879

Reference yield: 54.0%

1-bromo-4-tert-butylbenzene (3972-65-4) + butyraldehyde (123-72-8) → 1-(4-(tert-butyl)phenyl)butan-1-one (59477-80-4)

Guidance literature:

With nickel(II) iodide; potassium phosphate; tetrakis(tetrabutylammonium)decatungstate(VI); 4,4'-di-tert-butyl-2,2'-bipyridine; In acetonitrile; at 20 ℃; for 4h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.0c01121

upstream raw materials:

tert-butylbenzene

butyryl chloride

(4-(tert-butyl)phenyl)(cyclopropyl)methanone

benzene

Downstream raw materials:

1-(4-tert-butyl-phenyl)-butan-1-ol

C₁₄H₁₉BrO

C₁₈H₁₈N₄

1-(4-tert-butylphenyl)butane-1,2-dione