Technology Process of 1-<(tert-butyldimethylsilyl)oxy>-4-methylene-6-(phenylsulfonyl)hexane
There total 13 articles about 1-<(tert-butyldimethylsilyl)oxy>-4-methylene-6-(phenylsulfonyl)hexane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78 percent / NaH, bis(diphenylphosphino)ethane / bis(dibenzylideneacetone)palladium / tetrahydrofuran / 19 h / Ambient temperature
2: 79 percent / NaCl, H2O / dimethylsulfoxide / 10 h / Heating
3: 90 percent / p-toluenesulfonic acid monohydrate / methanol / 1.5 h / Ambient temperature
4: 83 percent / tri-n-butylphosphine, pyridine / 4.5 h / Ambient temperature
5: 76 percent / diphenyldiselenide, 30percent H2O2 / diethyl ether; CH2Cl2 / 0.83 h / 0 °C
6: 76 percent / LiAlH4 / diethyl ether / 0.33 h / -40 °C
7: 93 percent / imidazole / dimethylformamide / 3.5 h / Ambient temperature
With
pyridine; 1H-imidazole; lithium aluminium tetrahydride; tributylphosphine; diphenyl diselenide; water; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane; sodium chloride;
bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00096a016
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 300 °C
2: 78 percent / NaH, bis(diphenylphosphino)ethane / bis(dibenzylideneacetone)palladium / tetrahydrofuran / 19 h / Ambient temperature
3: 79 percent / NaCl, H2O / dimethylsulfoxide / 10 h / Heating
4: 90 percent / p-toluenesulfonic acid monohydrate / methanol / 1.5 h / Ambient temperature
5: 83 percent / tri-n-butylphosphine, pyridine / 4.5 h / Ambient temperature
6: 76 percent / diphenyldiselenide, 30percent H2O2 / diethyl ether; CH2Cl2 / 0.83 h / 0 °C
7: 76 percent / LiAlH4 / diethyl ether / 0.33 h / -40 °C
8: 93 percent / imidazole / dimethylformamide / 3.5 h / Ambient temperature
With
pyridine; 1H-imidazole; lithium aluminium tetrahydride; tributylphosphine; diphenyl diselenide; water; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; 1,2-bis-(diphenylphosphino)ethane; sodium chloride;
bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo00096a016
