5,6-Diphenylpyrazin-2-amine

Base Information

• Chemical Name: 5,6-Diphenylpyrazin-2-amine
• CAS No.: 41270-71-7
• Molecular Formula: C₁₆H₁₃N₃
• Molecular Weight: 247.299
• DSSTox Substance ID: DTXSID301309955
• Nikkaji Number: J613.432G
• Mol file: 41270-71-7.mol

Synonyms:5,6-diphenylpyrazin-2-amine;41270-71-7;5,6-Diphenyl-2-pyrazinamine;2-Amino-5,6-diphenylpyrazine;SCHEMBL2031287;BOIRYLPSITXMRA-UHFFFAOYSA-N;DTXSID301309955

Chemical Property of 5,6-Diphenylpyrazin-2-amine

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 247.110947427
• Heavy Atom Count: 19
• Complexity: 269

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC=C(N=C2C3=CC=CC=C3)N

Technology Process of 5,6-Diphenylpyrazin-2-amine

There total 9 articles about 5,6-Diphenylpyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-azido-5,6-diphenylpyrazine (76849-26-8) → 2-amino-5,6-diphenylpyrazine (41270-71-7)

Guidance literature:

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In 1,2-dimethoxyethane; for 1h; Ambient temperature; Parr hydrogenation apparatus;

DOI:10.1055/s-1994-25607

Reference yield: 87.0%

2,3-diphenyloxirane (1689-71-0,17619-97-5,25144-18-7,38628-70-5,40102-60-1,1439-07-2) + 2-amino-acetamidine dihydrobromide (69816-37-1) → 2-amino-5,6-diphenylpyrazine (41270-71-7)

Guidance literature:

With lithium bromide; In 1,4-dioxane; at 5 - 20 ℃; for 6h; Time; Reagent/catalyst; Molecular sieve; Inert atmosphere; Reflux;

Reference yield: 63.0%

2-chloro-5,6-diphenylpyrazine (41270-66-0) → 2-amino-5,6-diphenylpyrazine (41270-71-7)

Guidance literature:

With benzamide; potassium carbonate; at 180 - 230 ℃; for 1h;

upstream raw materials:

3-amino-5,6-diphenyl-pyrazine-2-carboxylic acid

2-chloro-5,6-diphenylpyrazine

2-azido-5,6-diphenylpyrazine

6,7-diphenylpteridine-2,4(1H,3H)-dione

Downstream raw materials:

1-Benzoyl-3-(5,6-diphenyl-pyrazin-2-yl)-thiourea