1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one

Base Information

Chemical Name:1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one
CAS No.:1346235-54-8
Molecular Formula:C₂₆H₂₉ClF₂N₈O₂
Molecular Weight:559.018
Hs Code.:

Synonyms:1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one

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Chemical Property of 1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one

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Technology Process of 1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one

There total 6 articles about 1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346235-34-4
C₁₅H₂₀ClN₅O

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1346235-54-8
1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: With triethylamine; In ethanol; for 8h; Reflux;
DOI:10.1016/j.ejmech.2011.03.019

Reference yield:

: 1346235-14-0
C₁₁H₁₁BrClN₃O

: 1346235-54-8
1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / ethanol / 8 h / 70 °C

2: triethylamine / ethanol / 8 h / Reflux

With potassium carbonate; triethylamine; In ethanol;
DOI:10.1016/j.ejmech.2011.03.019

Reference yield:

: 372-18-9
1,3-Difluorobenzene

: 1346235-54-8
1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-chlorophenyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 3 h / 40 °C

2: potassium carbonate / dichloromethane / 24 h / 20 °C

3: sodium hydroxide / toluene / 3 h / 60 °C

4: triethylamine / ethanol / 8 h / Reflux

With aluminum (III) chloride; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2011.03.019