3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol

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Chemical Name:3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol
CAS No.:896104-57-7
Molecular Formula:C₄₅H₇₂O₃Si₂
Molecular Weight:717.236
Hs Code.:

3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol

Synonyms:3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol

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Chemical Property of 3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol

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Technology Process of 3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol

There total 18 articles about 3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 896104-56-6
1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

: 896104-57-7
3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol

Guidance literature:: With 2,6-dimethylpyridine; bromocatecholborane; In dichloromethane; at 0 ℃; for 7h;
DOI:10.1021/jo0604585

Reference yield:

: 896104-51-1
(E)-(2S,3S)-2-[3-(4-Methoxy-benzyloxy)-propyl]-3-methyl-hex-4-enoic acid

: 896104-57-7
3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 80 percent / MsCl; Et₃N / tetrahydrofuran / 1 h / 0 °C

2.1: 82 percent / tetrahydrofuran / 20 °C

3.1: Grubbs catalyst / CH₂Cl₂ / Heating

4.1: H₂ / Pd/C / ethyl acetate / 2 h

5.1: LHMDS / toluene / 1 h / -78 °C

5.2: tetrahydrofuran / 4 h / -78 - 20 °C

6.1: HSnBu₃; Pd(PPh₃)4 / tetrahydrofuran / 2 h

6.2: 1.18 percent / Pd(PPh₃)4; LiCl; CuCl / dimethylsulfoxide / 37 h / 60 °C

7.1: 87 percent / DIBAL-H / CH₂Cl₂ / -78 - 20 °C

8.1: 93 percent / imidazole / dimethylformamide / 18 h / 20 °C

9.1: 91 percent / catecholborane bromide; 2,6-lutidine / CH₂Cl₂ / 7 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromocatecholborane; hydrogen; tri-n-butyl-tin hydride; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 6.2: Stille coupling;
DOI:10.1021/jo0604585

Reference yield:

: 896104-74-8
(2S,3S,4E)-N-methoxy-2-{3-[(4-methoxybenzyl)oxy]propyl}-N,3-dimethylhex-4-enamide

: 896104-57-7
3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 82 percent / tetrahydrofuran / 20 °C

2.1: Grubbs catalyst / CH₂Cl₂ / Heating

3.1: H₂ / Pd/C / ethyl acetate / 2 h

4.1: LHMDS / toluene / 1 h / -78 °C

4.2: tetrahydrofuran / 4 h / -78 - 20 °C

5.1: HSnBu₃; Pd(PPh₃)4 / tetrahydrofuran / 2 h

5.2: 1.18 percent / Pd(PPh₃)4; LiCl; CuCl / dimethylsulfoxide / 37 h / 60 °C

6.1: 87 percent / DIBAL-H / CH₂Cl₂ / -78 - 20 °C

7.1: 93 percent / imidazole / dimethylformamide / 18 h / 20 °C

8.1: 91 percent / catecholborane bromide; 2,6-lutidine / CH₂Cl₂ / 7 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromocatecholborane; hydrogen; tri-n-butyl-tin hydride; diisobutylaluminium hydride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 5.2: Stille coupling;
DOI:10.1021/jo0604585