4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine

Base Information

Chemical Name:4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine
CAS No.:1282522-77-3
Molecular Formula:C₂₁H₁₈ClN₅
Molecular Weight:375.86
Hs Code.:

Synonyms:4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine

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Chemical Property of 4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine

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Technology Process of 4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine

There total 5 articles about 4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1282522-76-2
(E)-1-(4-chlorophenyl)-3-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-propen-1-one

: 50-01-1
guanidine hydrochloride

: 1282522-77-3
4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine

Guidance literature:: With sodium hydroxide; In ethanol; water; for 6h; Reflux;
DOI:10.1248/cpb.58.1622

Reference yield:

: 22042-79-1
3,5-dimethyl-1-phenyl-1H-pyrazole-4-carbaldehyde

: 1282522-77-3
4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / 5 - 20 °C

2: sodium hydroxide / ethanol; water / 6 h / Reflux

With potassium hydroxide; sodium hydroxide; In ethanol; water; 1: Claisen condensation;

Reference yield:

: 1131-16-4
3,5-dimethyl-1-phenyl-1H-pyrazole

: 1282522-77-3
4-(4-chlorophenyl)-6-(3,5-dimethyl-1-phenyl-1H-4-pyrazolyl)-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.5 h

1.2: 0 °C / Reflux

2.1: potassium hydroxide / ethanol; water / 5 - 20 °C

3.1: sodium hydroxide / ethanol; water / 6 h / Reflux

With potassium hydroxide; sodium hydroxide; trichlorophosphate; In ethanol; water; 2.1: Claisen condensation;