methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate

Base Information

• Chemical Name: methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate
• CAS No.: 161392-59-2
• Molecular Formula: C₂₂H₄₁NO₄Si₂
• Molecular Weight: 439.743

Synonyms:methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate

Chemical Property of methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate

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Technology Process of methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate

There total 4 articles about methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

L-dopa methyl ester hydrochloride (1421-65-4) + tert-butyldimethylsilyl chloride (18162-48-6) → methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate (161392-59-2) + methyl (S)-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>-2-formylaminopropanoate

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 3.5h;

DOI:10.1016/S0040-4020(99)00133-7

Reference yield: 70.0%

L-dopa methyl ester hydrochloride (1421-65-4) + tert-butyldimethylsilyl chloride (18162-48-6) → methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate (161392-59-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In acetonitrile; for 18h; Ambient temperature;

Reference yield: 6.0%

L-dopa methyl ester hydrochloride (1421-65-4) + tert-butyldimethylsilyl chloride (18162-48-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate (161392-59-2) + methyl (S)-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>-2-formylaminopropanoate

Guidance literature:

With 1H-imidazole; for 3.5h;

DOI:10.1016/S0040-4020(99)00133-7

upstream raw materials:

L-dopa methyl ester hydrochloride

tert-butyldimethylsilyl chloride

N,N-dimethyl-formamide

levodopa

Downstream raw materials:

methyl (S)-2--3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate

methyl (S)-2--3-<2-bromo-4,5-(methylenedioxy)phenyl>propanoate

methyl (S)-3-<3,4-(methylenedioxy)phenyl>-2-propanoate

2--3-<2-bromo-4,5-(methylenedioxy)phenyl>propanoic acid

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