3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine

Base Information

Chemical Name:3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine
CAS No.:345912-61-0
Molecular Formula:C₁₈H₁₄ClN₅S
Molecular Weight:367.862
Hs Code.:

Synonyms:3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine

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Chemical Property of 3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine

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Technology Process of 3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine

There total 5 articles about 3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 345912-60-9
ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate

: 345912-61-0
3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: With hydrazine hydrate; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1080/10426500008076538

Reference yield:

: 134791-44-9
(E)-2-(4-chlorobenzylidene)cyclopentan-1-one

: 345912-61-0
3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / NaOMe / methanol / 48 h / 50 °C

2: 86 percent / AcONa*3H₂O / ethanol / 2 h / Heating

3: 90 percent / EtONa / ethanol / 0.08 h / Heating

4: 84 percent / Ac₂O / 5 h / Heating

5: 82 percent / N₂H₄*H₂O / dioxane / 1 h / 20 °C

With sodium methylate; sodium ethanolate; sodium acetate; acetic anhydride; hydrazine hydrate; In 1,4-dioxane; methanol; ethanol; 3: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500008076538

Reference yield:

: 83236-50-4
4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione

: 345912-61-0
3-amino-3,4-dihydro-4-imino-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido-[3',2':4,5]thieno[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / AcONa*3H₂O / ethanol / 2 h / Heating

2: 90 percent / EtONa / ethanol / 0.08 h / Heating

3: 84 percent / Ac₂O / 5 h / Heating

4: 82 percent / N₂H₄*H₂O / dioxane / 1 h / 20 °C

With sodium ethanolate; sodium acetate; acetic anhydride; hydrazine hydrate; In 1,4-dioxane; ethanol; 2: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500008076538