ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate

Base Information

Chemical Name:ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate
CAS No.:345912-60-9
Molecular Formula:C₂₀H₁₆ClN₃OS
Molecular Weight:381.886
Hs Code.:

Synonyms:ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate

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Technology Process of ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate

There total 4 articles about ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 122-51-0
orthoformic acid triethyl ester

: 345912-36-9
3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carbonitrile

: 345912-60-9
ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate

Guidance literature:: With acetic anhydride; for 5h; Heating;
DOI:10.1080/10426500008076538

Reference yield:

: 134791-44-9
(E)-2-(4-chlorobenzylidene)cyclopentan-1-one

: 345912-60-9
ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / NaOMe / methanol / 48 h / 50 °C

2: 86 percent / AcONa*3H₂O / ethanol / 2 h / Heating

3: 90 percent / EtONa / ethanol / 0.08 h / Heating

4: 84 percent / Ac₂O / 5 h / Heating

With sodium methylate; sodium ethanolate; sodium acetate; acetic anhydride; In methanol; ethanol; 3: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500008076538

Reference yield:

: 83236-50-4
4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione

: 345912-60-9
ethyl-N-[(4-p-chlorophenyl)-2-cyanocyclopenta[e]thieno[2,3-b]pyridin-3-yl]-methanimidate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / AcONa*3H₂O / ethanol / 2 h / Heating

2: 90 percent / EtONa / ethanol / 0.08 h / Heating

3: 84 percent / Ac₂O / 5 h / Heating

With sodium ethanolate; sodium acetate; acetic anhydride; In ethanol; 2: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500008076538