(S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate
CAS No.:1262537-08-5
Molecular Formula:C₂₁H₃₀FN₃O₃
Molecular Weight:391.486
Hs Code.:

Synonyms:(S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate

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Chemical Property of (S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate

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Technology Process of (S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate

There total 4 articles about (S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 857680-68-3
(S)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one

: 89711-08-0
N-(t-butoxycarbonyl)glycinal

: 1262537-08-5
(S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate

Guidance literature:: With MP-sodium triacetoxyborohydride resin; In tetrahydrofuran; dichloromethane; Inert atmosphere;

Reference yield:

: tert-butyl 4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate

: 1262537-08-5
(S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

1.2: Inert atmosphere

2.1: MP-sodium triacetoxyborohydride resin / dichloromethane; tetrahydrofuran / Inert atmosphere

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 857681-22-2
rac-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

: 1262537-08-5
(S)-tert-butyl 2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethyl acetate; water / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: Chiraltech OJ column / isopropyl alcohol; hexanes / 1.08 h / Resolution of racemate

4.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

4.2: Inert atmosphere

5.1: MP-sodium triacetoxyborohydride resin / dichloromethane; tetrahydrofuran / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; water; ethyl acetate; isopropyl alcohol;