Technology Process of (R)-6-but-3-enyl-1-iodo-5,5-dimethylcyclohexene
There total 1 articles about (R)-6-but-3-enyl-1-iodo-5,5-dimethylcyclohexene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-iodobut-1-ene;
With
zinc;
In
tetrahydrofuran;
at 40 ℃;
for 14h;
With
trimethylsilylmethyllithium;
In
tetrahydrofuran; pentane;
at -40 ℃;
for 1h;
phosphoric acid diethyl ester (R)-2-iodo-4,4-dimethylcyclohex-2-enyl ester;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; pentane;
at -30 - 25 ℃;
for 14h;
DOI:10.1021/ol049221q
- Guidance literature:
-
With
oxygen; copper dichloride;
palladium dichloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 48h;
DOI:10.1021/ol049221q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 82 percent / CuCl2; O2 / PdCl2 / dimethylformamide / 48 h / 20 °C
2: 70 percent / ZnCl2; dppf / Pd(dba)2 / tetrahydrofuran; diethyl ether / 24 h / 20 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; oxygen; copper dichloride; zinc(II) chloride;
palladium dichloride; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ol049221q
