C₁₈H₂₀ClFN₄O₂

Base Information

Chemical Name:C₁₈H₂₀ClFN₄O₂
CAS No.:1309377-57-8
Molecular Formula:C₁₈H₂₀ClFN₄O₂
Molecular Weight:378.834
Hs Code.:

C<sub>18</sub>H<sub>20</sub>ClFN<sub>4</sub>O<sub>2</sub>

Synonyms:C₁₈H₂₀ClFN₄O₂

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Chemical Property of C₁₈H₂₀ClFN₄O₂

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Technology Process of C₁₈H₂₀ClFN₄O₂

There total 7 articles about C₁₈H₂₀ClFN₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1309377-56-7
6-amino-3-fluoro-2-methylbenzonitrile

: 14052-82-5
4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidine

: 1309377-57-8
C₁₈H₂₀ClFN₄O₂

Guidance literature:: 6-amino-3-fluoro-2-methylbenzonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

4,6-dichloro-5-(2,2-diethoxyethyl)pyrimidine; In tetrahydrofuran; mineral oil; for 2.5h; Reflux;

Reference yield:

: 1255241-44-1
C₈H₅FN₂O₂

: 1309377-57-8
C₁₈H₂₀ClFN₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 760.05 Torr

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 2.5 h / Reflux

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; mineral oil;

Reference yield:

: 185147-06-2
3-fluoro-2-methylbenzonitrile

: 1309377-57-8
C₁₈H₂₀ClFN₄O₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium nitrate; sulfuric acid / 2 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 760.05 Torr

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

3.2: 2.5 h / Reflux

With sulfuric acid; hydrogen; sodium hydride; potassium nitrate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; mineral oil;