Technology Process of (1R,2S,7S,7aS)-1,2-Dihydroxy-7-(4-methoxybenzyloxy)hexahydro-1H-pyrrolizin-5-one
There total 11 articles about (1R,2S,7S,7aS)-1,2-Dihydroxy-7-(4-methoxybenzyloxy)hexahydro-1H-pyrrolizin-5-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
osmium(VIII) oxide; N-methyl-2-indolinone;
In
acetone;
at 20 ℃;
for 30h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: DIBAL-H / CH2Cl2 / 1.5 h / 0 - 20 °C
1.2: 63 percent / I2 / benzene / 1 h / 20 °C / UV-irradiation
2.1: 2.44 g / (COCl)2; DMSO; Et3N / dimethylsulfoxide / 1.92 h / -60 °C
3.1: 2.67 g / aq. NaClO2; NaH2PO4*H2O; 2-methylbut-2-ene / 2-methyl-propan-2-ol / 0.67 h / 0 - 20 °C
4.1: 2.32 g / pyridine / tetrahydrofuran / 20 h / 20 °C
5.1: 1.51 g / hydroxylamine hydrochloride; Et3N / CH2Cl2 / 3 h / 20 °C
6.1: Bu4NIO4 / CHCl3 / 2 h / 22 °C
7.1: 91 percent / Na(Hg); Na2HPO4 / ethanol / 14 h / 0 °C
8.1: Et3N / CH2Cl2 / 0.83 h / 0 - 20 °C
9.1: 326 mg / LDA / tetrahydrofuran / 2 h / -78 - 20 °C
10.1: 65 percent / aq. OsO4; NMO / acetone / 30 h / 20 °C
With
pyridine; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; osmium(VIII) oxide; N-methyl-2-indolinone; sodium amalgam; 2-methyl-but-2-ene; oxalyl dichloride; hydroxylamine hydrochloride; diisobutylaluminium hydride; tetrabutylammonium periodite; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; acetone; tert-butyl alcohol;
2.1: Swern oxidation;
- Guidance literature:
-
With
potassium osmate(VI); 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
tert-butyl alcohol;
at 22 ℃;
for 72h;
Further Variations:;
Reagents;
Solvents;
Time;
Product distribution;
