(Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

Base Information

Chemical Name:(Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester
CAS No.:334949-22-3
Molecular Formula:C₂₉H₂₉N₃O₃
Molecular Weight:467.568
Hs Code.:

Synonyms:(Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

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Chemical Property of (Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

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Technology Process of (Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

There total 11 articles about (Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: methyl 3-bromooxindole-6-carboxylate

: N-[4-(piperidin-1-ylmethyl)phenyl]thiobenzamide hydrochloride

: 334949-22-3
(Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/acs.joc.1c01269

Reference yield: 49.0%

: 67-56-1
methanol

: 334949-22-3
(Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: (Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid ethyl ester; With 1,1'-carbonyldiimidazole; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 14h;

methanol; In DMF (N,N-dimethyl-formamide); at 50 ℃; for 3h;

Reference yield: 49.0%

: 67-56-1
methanol

: (Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid

: 334949-22-3
(Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: (Z)-2-oxo-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 80 ℃; for 14h;

methanol; In N,N-dimethyl-formamide; at 50 ℃; for 3h;
DOI:10.1021/jm900431g