7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

Base Information

Chemical Name:7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile
CAS No.:797783-31-4
Molecular Formula:C₂₃H₁₂Cl₂N₂O₂
Molecular Weight:419.266
Hs Code.:

Synonyms:7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

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Chemical Property of 7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

Chemical Property:

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Technology Process of 7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

There total 8 articles about 7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-2-[4-(4-Chloro-benzoyl)-2-fluoro-benzoyl]-3-(3-chloro-phenylamino)-acrylonitrile

: 797783-31-4
7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

Guidance literature:: With potassium carbonate; In pentan-1-ol; at 110 ℃;
DOI:10.1016/j.bmcl.2004.08.012

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 797783-31-4
7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 67 percent / K₂CO₃; PdCl₂(dppf) / methoxybenzene / 80 °C

2: 95 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 70 °C

3: SOCl₂ / 0.25 h / 80 °C

4: NaH / toluene / 20 °C

5: TFA / CH₂Cl₂ / 3 h

6: toluene / 3 h / 20 °C

7: CH₂Cl₂ / 20 °C

8: K₂CO₃ / pentan-1-ol / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide; thionyl chloride; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; pentan-1-ol; methoxybenzene; toluene;
DOI:10.1016/j.bmcl.2004.08.012

Reference yield:

: 179232-29-2
methyl 4-bromo-2-fluorobenzoate

: 797783-31-4
7-(4-chloro-benzoyl)-1-(3-chloro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 67 percent / K₂CO₃; PdCl₂(dppf) / methoxybenzene / 80 °C

2: 95 percent / aq. LiOH / tetrahydrofuran / 1.5 h / 70 °C

3: SOCl₂ / 0.25 h / 80 °C

4: NaH / toluene / 20 °C

5: TFA / CH₂Cl₂ / 3 h

6: toluene / 3 h / 20 °C

7: CH₂Cl₂ / 20 °C

8: K₂CO₃ / pentan-1-ol / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide; thionyl chloride; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; pentan-1-ol; methoxybenzene; toluene;
DOI:10.1016/j.bmcl.2004.08.012