(6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone

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Chemical Name:(6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone
CAS No.:680208-34-8
Molecular Formula:C₂₀H₂₄FIN₄O₂
Molecular Weight:498.339
Hs Code.:

Synonyms:(6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone

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Chemical Property of (6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone

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Technology Process of (6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone

There total 9 articles about (6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 680208-33-7
(6-amino-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone

: 680208-34-8
(6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone

Guidance literature:: With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; In dichloromethane; at 20 ℃;

Reference yield:

: (+/-)-N-4-fluorobenzyl-trans-2,5-dimethylpiperazine

: 680208-34-8
(6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 6 steps

1: methanol / 2.5 h / 50 °C

2: sodium hydroxide / dichloromethane; water / 1.17 h / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 20 °C

4: ammonia / methanol / 60 °C

5: potassium tert-butylate / Heating / reflux

6: N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate / dichloromethane / 20 °C

With sodium hydroxide; potassium tert-butylate; ammonia; N,N,N-trimethylbenzenemethanaminium dichloroiodate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; calcium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 364066-92-2
(2S,5R)-1-(4-fluorobenzyl)-2,5-dimethylpiperazine

: 680208-34-8
(6-amino-5-iodo-2-methoxy-pyridin-3-yl)-[4-(4-fluoro-benzyl)-2R,5S-dimethyl-piperazin-1-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 20 °C

2: ammonia / methanol / 60 °C

3: potassium tert-butylate / Heating / reflux

4: N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate / dichloromethane / 20 °C

With potassium tert-butylate; ammonia; N,N,N-trimethylbenzenemethanaminium dichloroiodate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; calcium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;