bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate

Base Information

• Chemical Name: bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate
• CAS No.: 1404216-68-7
• Molecular Formula: C₅₉H₁₀₅N₄O₆P
• Molecular Weight: 997.48
• Mol file: 1404216-68-7.mol

Synonyms:bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate

Chemical Property of bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate

There total 3 articles about bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde (1166948-81-7) + bis[3-(octadecyloxy)propyl] (3-aminopropyl)phosphonate (1404216-67-6) → bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate (1404216-68-7)

Guidance literature:

4-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde; bis[3-(octadecyloxy)propyl] (3-aminopropyl)phosphonate; With methanol; at 60 ℃; for 18h;

With sodium tetrahydroborate; at 30 ℃; for 0.5h;

Reference yield:

benzyl N-(3-{bis[3-(octadecyloxy)propoxy]phosphoryl}propyl)carbamate (1404216-66-5) → bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate (1404216-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen; trifluoroacetic acid / palladium 10% on activated carbon / methanol / 40 °C / 760.05 Torr

2.1: methanol / 18 h / 60 °C

2.2: 0.5 h / 30 °C

With methanol; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol;

Reference yield:

3-octadecyloxy-1-propanol (17367-36-1) → bis[3-(octadecyloxy)propyl] [3-({[4-(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidin-7-yI]methyl}amino)propyl]phosphonate (1404216-68-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h

1.2: 2 h

2.1: hydrogen; trifluoroacetic acid / palladium 10% on activated carbon / methanol / 40 °C / 760.05 Torr

3.1: methanol / 18 h / 60 °C

3.2: 0.5 h / 30 °C

With methanol; oxalyl dichloride; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

3-octadecyloxy-1-propanol

4-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine-7-carbaldehyde

bis[3-(octadecyloxy)propyl] (3-aminopropyl)phosphonate

benzyl N-(3-{bis[3-(octadecyloxy)propoxy]phosphoryl}propyl)carbamate