Technology Process of 7α-(Benzyloxy)-3β-(tetrahydropyranyloxy)-5α-cholan-24-ol
There total 11 articles about 7α-(Benzyloxy)-3β-(tetrahydropyranyloxy)-5α-cholan-24-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
DOI:10.1021/jo00121a033
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 92 percent / PPTS / CH2Cl2 / Ambient temperature
2: 92 percent / LiAlH4 / tetrahydrofuran / 0 °C
3: 98 percent / imidazole / CH2Cl2 / Ambient temperature
4: 59 percent / CrO3, 3,5-dimethylpyrazole / CH2Cl2 / Ambient temperature
5: 71 percent / H2 / PtO2 / ethyl acetate / 2.5 h
6: 94 percent / K-Selectride / tetrahydrofuran / 5 h / 50 °C
7: 87 percent / NaH / dimethylformamide; tetrahydrofuran / 1.) overnight; 40 deg C, 20 min, 2.) 40 deg C, 10 h
8: 90 percent / TBAF / tetrahydrofuran
With
1H-imidazole; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; potassium tri-sec-butyl-borohydride;
platinum(IV) oxide;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a033
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 92 percent / PPTS / CH2Cl2 / Ambient temperature
2: 92 percent / LiAlH4 / tetrahydrofuran / 0 °C
3: 98 percent / imidazole / CH2Cl2 / Ambient temperature
4: 59 percent / CrO3, 3,5-dimethylpyrazole / CH2Cl2 / Ambient temperature
5: 71 percent / H2 / PtO2 / ethyl acetate / 2.5 h
6: 94 percent / K-Selectride / tetrahydrofuran / 5 h / 50 °C
7: 87 percent / NaH / dimethylformamide; tetrahydrofuran / 1.) overnight; 40 deg C, 20 min, 2.) 40 deg C, 10 h
8: 90 percent / TBAF / tetrahydrofuran
With
1H-imidazole; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; potassium tri-sec-butyl-borohydride;
platinum(IV) oxide;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00121a033
