166896-79-3Relevant academic research and scientific papers
Method of treating a viral infection by administering a steroid compound
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, (2008/06/13)
A method of treating a viral infection includes administering an effective amount of a compound having the following structure: STR1 or a pharmaceutically acceptable salt thereof. This compound treats the viral infection by suppressing the growth of a viral target cell. As one specific example, this compound may be used to treat HIV infection.
Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
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, (2008/06/13)
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also disclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
Synthesis of 24ξ-squalamine, an anti-infective steroidal polyamine
Pechulis,Bellevue III,Cioffi,Trapp,Fojtik,McKitty,Kinney,Frye
, p. 5121 - 5126 (2007/10/02)
Squalamine (1) is a novel steroidal polyamine which exhibits broad spectrum anti-infective activity. It inhibits the growth of bacteria, both Gram positive and Gram negative, and fungi. The synthesis of 24ξ-squalamine was accomplished in 17 steps from 3β-hydroxy-5-cholenic acid. The stereospecific introduction of the 7α-hydroxyl group was achieved by allylic oxidation followed by hydrogenation of the Δ5 olefin and reduction of the 7-keto group with K-selectride. The polyamine side chain was introduced via reductive amination of an appropriately functionalized 3-keto steroid with a suitably protected spermidine utilizing sodium cyanoborohydride as the reducing agent. The required 24-sulfate was introduced by selective sulfation of the 7α,24ξ-diol with sulfur trioxide-pyridine complex.
