(R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide

Base Information

Chemical Name:(R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide
CAS No.:1433722-27-0
Molecular Formula:C₂₁H₂₈N₂O₃
Molecular Weight:356.465
Hs Code.:

Synonyms:(R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide

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Technology Process of (R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide

There total 6 articles about (R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

: 1433722-21-4
(R)-5-((dibenzylamino)methyl)dihydrofuran-2(3H)-one

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1433722-27-0
(R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at -10 - -5 ℃; for 1.5h; Inert atmosphere;
DOI:10.1080/00397911.2015.1093146

Reference yield: 92.0%

: C₁₉H₂₃NO₃

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 1433722-27-0
(R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide

Guidance literature:: C₁₉H₂₃NO₃; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethyl acetate; at 0 - 5 ℃; for 0.166667h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; In tetrahydrofuran; ethyl acetate; at 0 - 25 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetlet.2016.07.059

Reference yield:

: 103-49-1
dibenzylamine

: 1433722-27-0
(R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / 24 h / 65 - 70 °C

2: sodium ethanolate / ethanol; tetrahydrofuran / 15 h / 5 - 20 °C / Inert atmosphere

3: lithium chloride / water; dimethyl sulfoxide / 20 h / 120 - 130 °C / Inert atmosphere

4: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -10 - -5 °C / Inert atmosphere

With isopropylmagnesium chloride; sodium ethanolate; lithium chloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2013.03.051