quinolin-2-yl 4-methylbenzenesulfonate

Base Information

• Chemical Name: quinolin-2-yl 4-methylbenzenesulfonate
• CAS No.: 74857-16-2
• Molecular Formula: C₁₆H₁₃NO₃S
• Molecular Weight: 299.35
• Mol file: 74857-16-2.mol

Synonyms:quinolin-2-yl 4-methylbenzenesulfonate

Chemical Property of quinolin-2-yl 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of quinolin-2-yl 4-methylbenzenesulfonate

There total 12 articles about quinolin-2-yl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Quinoline N-oxide (1613-37-2) + p-toluenesulfonyl chloride (98-59-9) → quinolin-2-yl 4-methylbenzenesulfonate (74857-16-2)

Guidance literature:

With potassium carbonate; In 1,2-dichloro-ethane; at 100 ℃; for 12h; regioselective reaction; Schlenk technique;

DOI:10.1002/cctc.201600555

Reference yield: 82.0%

2-hydroxyquinoline (59-31-4) + p-toluenesulfonyl chloride (98-59-9) → quinolin-2-yl 4-methylbenzenesulfonate (74857-16-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/ol201706t

Reference yield: 46.0%

Quinoline N-oxide (1613-37-2) + p-toluenesulfonyl chloride (98-59-9) → N-(2-quinolyl)-2-quinolone (10168-37-3) + 2,2'-diquinolyl ether (74857-04-8) + quinolin-2-yl 4-methylbenzenesulfonate (74857-16-2) + 2-quinolone (59-31-4,70254-42-1,493-62-9)

Guidance literature:

With triethylamine; In chloroform; water; for 12h; Product distribution; Mechanism; Ambient temperature; other solvents;

DOI:10.1248/cpb.28.424

upstream raw materials:

2-hydroxyquinoline

p-toluenesulfonyl chloride

Quinoline N-oxide

6-methoxyquinoline N-oxide

Downstream raw materials:

1,2,3,4-tetrahydroisoquinoline

2-(2,3,5,6-tetrafluorophenyl)quinoline

2-(pentafluorophenyl)quinoline

(E)-2-(4-cinnamyl-2,3,5,6-tetrafluorophenyl)quinoline