methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate

Base Information

• Chemical Name: methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate
• CAS No.: 123843-22-1
• Molecular Formula: C₁₈H₁₇NO₅S
• Molecular Weight: 359.403
• Mol file: 123843-22-1.mol

Synonyms:methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate

Chemical Property of methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate

There total 3 articles about methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indole-3-acetic acid (87-51-4) → methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate (123843-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) hexane, THF, -70 deg C, 1 h; 2.) THF, r.t., overnight

2: 6.24 g / CH₂Cl₂; diethyl ether

With n-butyllithium; In diethyl ether; dichloromethane;

DOI:10.1002/hlca.19890720209

Reference yield:

4-methoxy-phenyl-sulphonyl chloride (98-68-0) → methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate (123843-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) hexane, THF, -70 deg C, 1 h; 2.) THF, r.t., overnight

2: 6.24 g / CH₂Cl₂; diethyl ether

With n-butyllithium; In diethyl ether; dichloromethane;

DOI:10.1002/hlca.19890720209

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 1-[(4-methoxyphenyl)sulfonyl]-1H-3-indole-3-acetic acid (888504-80-1) → methyl N-(p-methoxybenzenesulfonyl)-3-indoleacetate (123843-22-1)

Guidance literature:

In diethyl ether; dichloromethane;

DOI:10.1002/hlca.19890720209

upstream raw materials:

diazomethane

1-[(4-methoxyphenyl)sulfonyl]-1H-3-indole-3-acetic acid

indole-3-acetic acid

4-methoxy-phenyl-sulphonyl chloride

Downstream raw materials:

N-(p-methoxybenzenesulfonyl)-3-indoleacetaldehyde

Refernces