methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate

Base Information

Chemical Name:methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate
CAS No.:1083077-84-2
Molecular Formula:C₂₁H₂₀N₂O₅S
Molecular Weight:412.466
Hs Code.:

Synonyms:methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate

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Chemical Property of methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate

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Technology Process of methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate

There total 4 articles about methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1083077-81-9
N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

: 1083077-82-0
C₂₁H₂₀N₂O₅S

: 1083077-84-2
methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate

: cis-methyl 1-[(1-phenylsulfonylindol-2-yl)methyl]-4-methyl-2-azetidinone-3-carboxylate

: trans-methyl 1-[(1-phenylsulfonylindol-2-yl)methyl]-4-methyl-2-azetidinone-3-carboxylate

Guidance literature:: With rhodium(II) acetate dimer; In dichloromethane; at 20 ℃; optical yield given as %de; Inert atmosphere; Reflux;
DOI:10.1039/b809890e

Reference yield: 31.0%

: 1083077-81-9
N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

: 1083077-84-2
methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate

: cis-methyl 1-[(1-phenylsulfonylindol-2-yl)methyl]-4-methyl-2-azetidinone-3-carboxylate

: trans-methyl 1-[(1-phenylsulfonylindol-2-yl)methyl]-4-methyl-2-azetidinone-3-carboxylate

: methyl 2-ethyl-2,3,3b,8-tetrahydro-3-oxo-8-(phenylsulfonyl)-pyrrolo[3',4':1,3]cycloprop[1,2-b]indol-3a(1H)-carboxylate

Guidance literature:: With dirhodium tetraacetate; In dichloromethane; at 20 ℃; for 72h; chemoselective reaction; Inert atmosphere;
DOI:10.1039/c2ob25103e

Reference yield:

: 2-(N-ethylaminomethyl)-1-phenylsulfonylindole

: 1083077-84-2
methyl1-[(1-phenylsulfonylindol-2-yl)methyl]-2-pyrrolidinone-3-carboxylate

: cis-methyl 1-[(1-phenylsulfonylindol-2-yl)methyl]-4-methyl-2-azetidinone-3-carboxylate

: trans-methyl 1-[(1-phenylsulfonylindol-2-yl)methyl]-4-methyl-2-azetidinone-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / dichloromethane / 1.33 h / 0 - 20 °C / Inert atmosphere

2: dirhodium tetraacetate / dichloromethane / 72 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; dirhodium tetraacetate; In dichloromethane;
DOI:10.1039/c2ob25103e