N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

Base Information

Chemical Name:N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide
CAS No.:1083077-81-9
Molecular Formula:C₂₁H₂₀N₄O₅S
Molecular Weight:440.48
Hs Code.:

Synonyms:N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

Suppliers and Price of N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

There total 5 articles about N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2-(N-ethylaminomethyl)-1-phenylsulfonylindole

: 60180-61-2
methyl diazomalonyl chloride

: 1083077-81-9
N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 1.33333h; Inert atmosphere;
DOI:10.1039/c2ob25103e

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1083077-81-9
N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C

1.2: 2 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

3.1: sodium cyanoborohydride / methanol / 20 °C

4.1: 2,6-dimethylpyridine / dichloromethane / 1.33 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; 18-crown-6 ether; potassium tert-butylate; sodium cyanoborohydride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/c2ob25103e

Reference yield:

: 80360-23-2
1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

: 1083077-81-9
N-ethyl-N-[(1-phenylsulfonylindol-2-yl)methyl]-α-carbomethoxy-α-diazoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride / methanol / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 1.33 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium cyanoborohydride; In methanol; dichloromethane;
DOI:10.1039/c2ob25103e