C₁₉H₁₀ClF₂N₃O₂

Base Information

• Chemical Name: C₁₉H₁₀ClF₂N₃O₂
• CAS No.: 1346665-81-3
• Molecular Formula: C₁₉H₁₀ClF₂N₃O₂
• Molecular Weight: 385.757
• Mol file: 1346665-81-3.mol

Synonyms:C₁₉H₁₀ClF₂N₃O₂

Chemical Property of C₁₉H₁₀ClF₂N₃O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₀ClF₂N₃O₂

There total 3 articles about C₁₉H₁₀ClF₂N₃O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-(6-chlorobenzo[c][1,2,5]oxadiazol-5-yl)aniline (1346665-78-8) + 2,6-difluorobenzoylchloride (18063-02-0) → C19H10ClF2N3O2 (1346665-81-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

Reference yield:

2-nitro-4-bromo-5-chloro-aniline (827-33-8) → C19H10ClF2N3O2 (1346665-81-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol / 2 h / 60 °C

1.2: 2 h / 20 °C / Cooling with ice

2.1: triethyl phosphite / ethanol / 4 h / 79 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; acetonitrile; water / 1 h / 95 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; triethyl phosphite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

6-Bromo-5-chlorobenzo[c][1,2,5]oxadiazole 1-oxide (1346665-76-6) → C19H10ClF2N3O2 (1346665-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triethyl phosphite / ethanol / 4 h / 79 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; acetonitrile; water / 1 h / 95 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; triethyl phosphite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;

upstream raw materials:

4-(6-chlorobenzo[c][1,2,5]oxadiazol-5-yl)aniline

2,6-difluorobenzoylchloride

2-nitro-4-bromo-5-chloro-aniline

6-Bromo-5-chlorobenzo[c][1,2,5]oxadiazole 1-oxide