(3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

Base Information

Chemical Name:(3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline
CAS No.:158705-95-4
Molecular Formula:C₁₈H₁₉NO₃
Molecular Weight:297.354
Hs Code.:

Synonyms:(3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

Suppliers and Price of (3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

Chemical Property:

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Technology Process of (3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

There total 7 articles about (3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 158705-94-3
(3S,4R)-(-)-4-(tert-butyldiphenylsilyloxy)-6,7-dimethoxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

: 158705-95-4
(3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.1016/0957-4166(94)80127-4

Reference yield:

: 158666-69-4
(R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile

: 158705-95-4
(3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 5 h / Heating

2: NaBH₄ / diethyl ether; methanol

3: 95 percent / DMAP, Et₃N / CH₂Cl₂ / Ambient temperature

4: 94 percent / PCl₅ / CH₂Cl₂ / 3 h / Ambient temperature

5: 88 percent / Bu₄NF / tetrahydrofuran / 24 h / Ambient temperature

With dmap; sodium tetrahydroborate; phosphorus pentachloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/0957-4166(94)80127-4

Reference yield:

: (R)-2-(tert-Butyl-diphenyl-silanyloxy)-2-(3,4-dimethoxy-phenyl)-1-phenyl-ethylideneamine

: 158705-95-4
(3S,4R)-(+)-6,7-dimethoxy-4-hydroxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / diethyl ether; methanol

2: 95 percent / DMAP, Et₃N / CH₂Cl₂ / Ambient temperature

3: 94 percent / PCl₅ / CH₂Cl₂ / 3 h / Ambient temperature

4: 88 percent / Bu₄NF / tetrahydrofuran / 24 h / Ambient temperature

With dmap; sodium tetrahydroborate; phosphorus pentachloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/0957-4166(94)80127-4