(R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile

Base Information

Chemical Name:(R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile
CAS No.:158666-69-4
Molecular Formula:C₂₆H₂₉NO₃Si
Molecular Weight:431.607
Hs Code.:

Synonyms:(R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile

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Chemical Property of (R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile

Chemical Property:

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Technology Process of (R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile

There total 1 articles about (R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 158705-89-6
(R)-(+)-2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

: 158666-69-4
(R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 2h;
DOI:10.1016/0957-4166(94)80127-4

Reference yield:

: 158666-69-4
(R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile

: 158705-92-1
(1S,2R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-dimethoxyphenyl)-phenylethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 5 h / Heating

2: NaBH₄ / diethyl ether; methanol

With sodium tetrahydroborate; In methanol; diethyl ether;
DOI:10.1016/0957-4166(94)80127-4

Reference yield:

: 158666-69-4
(R)-(-)-2-(tert-butyldiphenylsilyloxy)-2-(3,4-di-methoxyphenyl)acetonitrile

: (1R,3S,4R)-(+)-6,7-dimethoxy-1,N-dimethyl-4-hydroxy-3-phenyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether / 5 h / Heating

2: NaBH₄ / diethyl ether; methanol

3: 95 percent / DMAP, Et₃N / CH₂Cl₂ / Ambient temperature

4: 94 percent / PCl₅ / CH₂Cl₂ / 3 h / Ambient temperature

5: 88 percent / Bu₄NF / tetrahydrofuran / 24 h / Ambient temperature

6: 85 percent / NaBH₄ / methanol / Ambient temperature

7: 92 percent / NaBH₃CN / acetonitrile; H₂O / 12 h / Ambient temperature

With dmap; sodium tetrahydroborate; phosphorus pentachloride; tetrabutyl ammonium fluoride; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/0957-4166(94)80127-4