(R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine

Base Information

Chemical Name:(R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine
CAS No.:140176-65-4
Molecular Formula:C₂₃H₂₃F₂NO₂
Molecular Weight:383.438
Hs Code.:

Synonyms:(R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine

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Chemical Property of (R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine

Chemical Property:

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Technology Process of (R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine

There total 9 articles about (R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 140176-69-8
(R,E)-2-(benzyloxy)-3,3-difluoro-3-phenylpropanal O-benzylamine

: 140176-65-4
(R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine

Guidance literature:: With hydrogenchloride; sodium cyanoborohydride; In methanol; for 1h;
DOI:10.1021/jo00035a035

Reference yield:

: 622-33-3
N-benzyloxyamine

: 140176-65-4
(R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / AcOH, molelcular sieves (4 Angstroem) / ethanol

2: 80 percent / NaBH₃CN, HCl (pH 3) / methanol / 1 h

With hydrogenchloride; 4 A molecular sieve; sodium cyanoborohydride; acetic acid; In methanol; ethanol;
DOI:10.1021/jo00035a035

Reference yield:

: 100-39-0
benzyl bromide

: 140176-65-4
(R)-N-1-<2-(benzyloxy)-3,3-difluoro-3-phenylpropyl>-O-benzylhydroxylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / NaH / dimethylformamide / 0.17 h / 20 °C

2: 2,4,6-trimethylpyridine / acetonitrile / 0.5 h / Ambient temperature

3: HgCl₂ / H₂O / 2 h / 0 °C

4: 79 percent / AcOH, molelcular sieves (4 Angstroem) / ethanol

5: 80 percent / NaBH₃CN, HCl (pH 3) / methanol / 1 h

With 2,4,6-trimethyl-pyridine; hydrogenchloride; 4 A molecular sieve; sodium hydride; sodium cyanoborohydride; acetic acid; mercury dichloride; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00035a035