Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester

Base Information

• Chemical Name: Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester
• CAS No.: 871102-22-6
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 871102-22-6.mol

Synonyms:Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester

Chemical Property of Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester

There total 3 articles about Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Formic acid 2-[(R)-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester (871102-18-0) + benzoyl chloride (98-88-4) → Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1Z)-ylidene]-propyl ester (871102-20-4) + Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester (871102-22-6)

Guidance literature:

With trifluorormethanesulfonic acid; In benzene; at 20 ℃; for 10h;

DOI:10.1016/j.tet.2005.08.091

Reference yield:

6-azaspiro<4.5>decane-1,7-dione (71046-46-3) → Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester (871102-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.2: 82 percent / tetrahydrofuran / 2 h / -78 °C

2.1: 89 percent / triflic acid / 20 °C

3.1: 150 mg / triflic acid / benzene / 10 h / 20 °C

With trifluorormethanesulfonic acid; tert.-butyl lithium; In tetrahydrofuran; benzene;

DOI:10.1016/j.tet.2005.08.091

Reference yield:

(1R,5R)-1-Hydroxy-1-isopropenyl-6-aza-spiro[4.5]decan-7-one → Formic acid 2-[(R)-6-benzoyl-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester (871102-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / triflic acid / 20 °C

2: 150 mg / triflic acid / benzene / 10 h / 20 °C

With trifluorormethanesulfonic acid; In benzene;

DOI:10.1016/j.tet.2005.08.091

upstream raw materials:

Formic acid 2-[(R)-7-oxo-6-aza-spiro[4.5]dec-(1E)-ylidene]-propyl ester

benzoyl chloride

6-azaspiro<4.5>decane-1,7-dione